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The defective Sirt1 may be correlated to the abnormal IFNgamma expression in Severe aplastic anemia SAA patients and activation of Sirt1 signaling may help improve the inflammatory status of SAA. Study showed that epithelial-mesenchymal transition EMT is closely correlated with PD-L1 expression by pancreatic ductal adenocarcinoma cells and with an immunosuppressive.
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